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KMID : 0363219950330020314
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Korean Journal of Dermatology
1995 Volume.33 No. 2 p.314 ~ p.321
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Amorolfine Nail Lacquer 5% One Weekly in Onychomycosis of Fingers and/or Toes
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권경술
김수찬/이재승/갬방순/정병수/장승호/박천욱/김계정/이주홍
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Abstract
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Backgound :
@EN Amorolfine is a new topical antifungal drug of the morpholine class has broad spectrum fungicidal activity. Amorolfine nail lacquer 5% is a transungual delivery system which can penetrate well through the nail plate to the infected keratin
and
remain there for a prolonged period.
@ES Objective :
@EN The aim of this study is to assess the efficacy and tolerability of 5% amorolfine nail lacquer given once weekly to the patients with onychomycosis.
@ES Methods :
@EN 29 patients with onychomycosis affecting not more than 80% of the surface of nail were treated once weekly for up to 9 months with amorolfine nail lacquer 5%. Clinical and mycological examination were performed before treatment and 3, 6, 9
months
after start of treatment. Final evaluation was done 3 months after the end of treatment.
@ES Results :
@EN Average affected area(%) and average score of clinical signs-thickening, splitting, discoloration-were significantly decreased 3 months after start of treatment. Mycological cure rate was continuously increased according to the treatment
duration
reaching 75.9% at 3 months after treatment. Overall efficacy assessed by the investgators were cure in 31.0% and improvement in 41.4%. Tolerability, mode and frequency of treatment, and formulation were evaluated as good or excellent by most of
the
patients.No systemic or local side effect was observed.
@ES Conclusion :
@EN Amorolfine nail lacquer 5% used once weekly up to 9 months was relatively effective and safe for the treatment of onychomycosis. (Kor J Dermatol 1995;33(2) : 314~321)
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